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Japanese and Korean stock markets opened slightly lower, with the Nikkei 225 index down 0.02% at 39,357.77. South Korea's KOSPI index opened down 0.2% to 2,412.15 points.Guotai Junan's annual strategy for innovative drugs in 2025: innovative pharmaceutical companies have accelerated into the harvest period, and the valuation has been at a historical low in the past five years. Guotai Junan said that the centralized purchasing policy has become stable, mature and normalized, and the marginal impact has weakened. Innovative drugs have gained policy inclination in the medical insurance negotiation. In the past two years, the policy has continued to promote pharmaceutical innovation, and the top-level design and local supporting chain support the development of innovative drugs. Commercial insurance is expected to bring new growth momentum to China's pharmaceutical market, and the overall industry trend is upward. At present, the trend of innovative drug industry is improving, the supply continues to accelerate, and a number of domestic innovative drugs are approved soon, which is expected to drive a new round of heavy volume. At the same time, the commercialization has achieved remarkable results and has occupied a dominant position in some sub-sectors. Pharma's performance continued to differentiate, and innovative drugs and just-needed drugs performed well. Biotech commercialization continues to increase, per capita yield continues to increase, the node of turning losses is approaching, and innovation ushers in the harvest period. Horizontal comparison: compared with overseas peers, the overall valuation of domestic innovative pharmaceutical companies is in a historically low range; Vertical comparison: the valuation of SW- pharmaceutical biology and SW- chemical preparations is at a historical low in the past five years, and it is expected that the valuation of subsequent sectors will pick up.South Korean Finance Minister and US Treasury Secretary Yellen confirmed that they will work closely together.

Syrian opposition forces claimed to have taken control of the eastern Syrian city of Deir ez-Zor. According to Al Jazeera and Arabiya TV, on the 10th local time, Hassan Abdel Ghani, commander of Syrian opposition forces, said that "the eastern Syrian city of Deir ez-Zor has been completely controlled".Nippon Steel's share price rose by 1.2% shortly after the opening on Wednesday, and it is basically flat at present. In the news, US President Biden plans to formally prevent Nippon Steel from acquiring American steel companies for $14.1 billion. American steel stocks plunged overnight, once falling by 22%, and finally closed down by 9.7%.Trump appointed TOM BARRACK as the US ambassador to Turkey.

Goldman Sachs: I don't agree that gold can't reach $3,000 under a strong dollar. Goldman Sachs said that we don't agree with the view that the price of gold can't rise to $3,000 per ounce by the end of 2025 when the dollar remains strong for a long time. We predict that gold will reach $3,000 per ounce by the end of 2025, and the reduction of interest rate cuts by the Federal Reserve (rather than the strengthening of the US dollar) is the downside risk of this prediction.The chief operating officer of BlackRock seeks to improve its technical and artificial intelligence capabilities. The chief operating officer of BlackRock, the world's largest asset management company, said on Tuesday that the company is looking for opportunities to expand its technical capabilities, including in the field of artificial intelligence. Rob Goldstein, chief operating officer of BlackRock, said in an interview at a conference in new york: "There are always some capabilities that can be improved."China Huaneng and Huawei signed a strategic cooperation agreement. On December 6th, China Huaneng Group Co., Ltd. (hereinafter referred to as "Huaneng") and Huawei Technologies Co., Ltd. (hereinafter referred to as "Huawei") signed a strategic cooperation agreement. Wen Shugang, Chairman and Party Secretary of Huaneng Group, held talks and witnessed the signing of the contract with Meng Wanzhou, rotating chairman and CFO of Huawei, and jointly unveiled Huaneng-Huawei New Energy joint innovation lab. According to the agreement, the two sides will continue to deepen strategic cooperation in the fields of clean energy cooperation, digital transformation cooperation, the establishment of joint innovation lab, and corporate culture exchange.